Morpholine → 4-(3-Chloropyrazin-2-YL)morpholine
반응식
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>CN(C)C=O>[Cl:8][C:7]1[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:3][CH:4]=[CH:5][N:6]=1참가 물질
4
실험 절차
A mixture of 2,3-dichloropyrazine (5 g., 0.034 mmole), morpholine (5.8 g., 0.067 mmole), and 50 ml. of dimethylformamide are heatd at 90°-120° C. for 6-14 hours, in an atmosphere of nitrogen. The reaction mixture is cooled and evaporated to dryness at a water-bath temperature of 55° C. A chloroform solution of the residue is extracted twice with 0.1 M sodium hydroxide, dried over magnesium sulfate and evaporated to leave the product.
후처리
- temperatureThe reaction mixture is cooled
- customevaporated to dryness at a water-bath temperature of 55° C
- extractionA chloroform solution of the residue is extracted twice with 0.1 M sodium hydroxide
- dry with materialdried over magnesium sulfate
- customevaporated
- customto leave the product
출처 및 근거
- ORD 기록
- ord-65580d25f3c146bd866873d7acc15506
- 출처 데이터셋
- uspto-grants-1982_08
- 특허 번호
- US04343802
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