Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 2-((2-Chloroanilino)methyl)-2-imidazoline p-toluenesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 1,2-Ethanediamine, 4-methylbenzenesulfonate (1:?) | HCID 225030 | — |
| 반응물 | HCID 12832554 | HCID 12832554 | — |
| 반응물 | HCID 13123534 | HCID 13123534 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | 2-((2-Chloroanilino)methyl)-2-imidazoline p-toluenesulfonate | HCID 20529068 | — |
반응 단계
The compound 2-((2-chloroanilino)methyl)-2-imidazoline p-toluenesulfonate was prepared using substantially the same procedure described above by heating a mixture of o-chloroanilinoacetonitrile (43.9 g), ethylenediamine p-toluenesulfonate (61.5 g) and 1,2-dichlorobenzene (198 ml). The p-toluenesulfonate salt was hydrolyzed to the free base, i.e., 2-((2-chloroanilino)methyl)-2-imidazoline by slurrying the p-toluenesulfonate salt in water, basifying the slurry and extracting the mixture with CH2Cl2. The methylene chloride was evaporated leaving 38.0 g of the free base. The free base was put in solution in isopropyl alcohol and acidified with hydrochloric acid in isopropyl alcohol which resulted in crystal formation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343810 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-ff23076f9cdd42e0951ae0a9c3896e80 |
| 출처 메모 | uspto-grants-1982_08 |