1,2-Ethanediamine, 4-methylbenzenesulfonate (1:?) → p-Toluenesulfonic acid

HRID 66768

반응식

HRID 66768 반응식
CC1C=CC(SCC#N)=CC=1.[C:12]1([CH3:22])[CH:17]=[CH:16][C:15]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1.C(N)CN>ClC1C=CC=CC=1Cl.C(Cl)Cl>[CH3:22][C:12]1[CH:17]=[CH:16][C:15]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 2250301,2-Ethanediamine, 4-methylbenzenesulfonate (1:?)HCID 27997712-[(4-Methylphenyl)thio]acetonitrile

생성물 1

HCID 6101p-Toluenesulfonic acid

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 72391,2-Dichlorobenzene용매

실험 절차

A mixture of 27 g of 4-methylthiophenoxyacetonitrile and 35 g of ethylenediamine p-toluenesulfonate in 50 ml of 1,2-dichlorobenzene was heated at 158°-180° C. for about 45 minutes. The reaction mixture was cooled, diluted with CH2Cl2 and filtered to obtain the p-toluenesulfonate salt. After washing with CH2Cl2, the p-toluenesulfonate salt was slurried with water and then 40 ml of an aqueous 5 normal (N) sodium hydroxide solution added to the slurry. Extracting the mixture with CH2Cl2 and then evaporating the CH2Cl2 left 30 g of the free base. The free base was heated in cyclohexane/methylchloroform, the resulting mixture was then cooled and the solids removed by filtration. The free base was then dissolved in 150 ml of isopropanol and acidified with hydrochloric acid (HCl) in isopropanol to give the hydrochloride salt (31 g). The 2-((4-(methylthio)phenoxy)methyl)-2-imidazoline hydrochloride was found to have a m.p. of 190°-191° C.

후처리

  1. temperaturewas heated at 158°-180° C. for about 45 minutes
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-a440dca77bc945aeab5a44eccc4bab0c
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343808

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