Dimethylformamide → 3-Cyanophenoxyacetonitrile

HRID 66769노트

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HRID 66769 반응식
[C:1]([C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1)#[N:2].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.Cl[CH2:22][C:23]#[N:24]>O>[C:1]([C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[O:9][CH2:22][C:23]#[N:24])#[N:2]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 133943-Cyanophenol

생성물 1

HCID 205290533-Cyanophenoxyacetonitrile

시약·촉매·용매 1

HCID 962Water용매

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온도
70 °C

실험 절차

The compound 3-cyanophenoxyacetonitrile was prepared by heating 20.0 g of 3-cyanophenol, 30.1 g of anhydrous potassium carbonate and 30 ml of dimethylformamide with stirring in a 250 ml round-bottomed three-necked flask to 70° C. and then 12.7 g of chloroacetonitrile was added dropwise over a 15 minute period with cooling. The temperature of the mixture was held at 70°-80° C. for three hours, after which time the reaction mixture was poured into approximately 700 ml of ice and water which resulted in crystal formation. The crystals were separated by filtering and then washed thoroughly with water. After drying in a vacuum oven, a tan solid 3-cyanophenoxyacetonitrile was obtained.

후처리

  1. customThe compound 3-cyanophenoxyacetonitrile was prepared
  2. temperaturewith cooling
  3. customresulted in crystal formation
  4. customThe crystals were separated
  5. filtrationby filtering
  6. washwashed thoroughly with water
  7. customAfter drying in a vacuum oven

출처 및 근거

ORD 기록
ord-cb74929a9ac24f9fa00d273291c0ed94
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343808

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