Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 66774생성일: 2026년 10월 26일
O-Toluidine → Ethyl 8-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylate Hydrochloride
https://huagongshe.com/reaction/66774
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | O-Toluidine | HCID 7242 | — |
| 반응물 | 3-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl ester | HCID 304557 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Ethyl 8-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylate Hydrochloride | HCID 20529026 | — |
반응 단계
To a solution of 5.31 g (19.98 mmoles) of ethyl 4-chloro-8-methoxy-3-quinolinecarboxylate dissolved in 40 ml of tetrahydrofuran was added 2.15 g (20.06 mmoles) of o-toluidine dissolved in 40 ml of tetrahydrofuran. The solution was stirred with exclusion of moisture at 60° C. for 18 hours. The yellow solid precipitate was filtered and washed with isopropyl ether; yield 7.13 g (95.7%). The product was recrystallized three times from methylene chloride: ethyl acetate, m.p. 191°-193.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04343804 |
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| 출처 데이터셋 | uspto-grants-1982_08 |
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| ORD ID | ord-97812384425e455ea7ccbb58d5853e9b |
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| 출처 메모 | uspto-grants-1982_08 |
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