Phenylacetic Acid → 4-Hydroxy-4-(1-carboxy-1-phenyl-methyl)piperidine-1-carboxylic acid tert-butyl ester

반응식

[C:11](=[O:12])([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[N:18]1[CH2:19][CH2:20][C:21](=[O:24])[CH2:22][CH2:23]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[OH:1][C:2](=[O:3])[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1>>[OH:1][C:2](=[O:3])[CH:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[C:21]1([OH:24])[CH2:20][CH2:19][N:18]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:23][CH2:22]1

참가 물질

반응물 3

HCID 999Phenylacetic Acid

HCID 8028Tetrahydrofuran

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

생성물 1

HCID 670465474-Hydroxy-4-(1-carboxy-1-phenyl-methyl)piperidine-1-carboxylic acid tert-butyl ester

출처 및 근거

ORD 기록: ord-951a4567f99b4a3ab4e68aebf5b8a51d
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

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