Itaconic acid → N-Decyl-3-[3-(4-carboxy-2-oxo-pyrrolidino)phenyl]propenamide

HRID 66795

반응식

HRID 66795 반응식
[CH2:1]([NH:11][C:12](=[O:22])[CH:13]=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[C:23]([OH:31])(=[O:30])[C:24]([CH2:26][C:27](O)=[O:28])=[CH2:25]>C(OCC)(=O)C>[CH2:1]([NH:11][C:12](=[O:22])[CH:13]=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N:21]2[CH2:25][CH:24]([C:23]([OH:31])=[O:30])[CH2:26][C:27]2=[O:28])[CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

4

반응물 2

HCID 811Itaconic acidHCID 53861940N-decyl-3-(3-aminophenyl)propenamide

생성물 1

HCID 53878346N-Decyl-3-[3-(4-carboxy-2-oxo-pyrrolidino)phenyl]propenamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 9.0 g. of N-decyl-3-(3-aminophenyl)propenamide and 3.9 g. of itaconic acid was heated as a melt at 140°-145° C. for 1 hour, and then ca. 70 ml. of ethyl acetate was added to the hot mass. The resulting mixture was stirred, and a solid appeared. The mixture was cooled to room temperature, and the solid was recovered by filtration to give 9.5 g. of the title compound. This product was recrystallized from acetonitrile to give 8.4 g. (69% yield) of product having a melting point of 152.5°-153.5° C.

후처리

  1. additionA mixture of 9.0 g
  2. filtrationthe solid was recovered by filtration
  3. customto give 9.5 g

출처 및 근거

ORD 기록
ord-5db9f24c72b74b83ad7151b3a67c7621
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343813

연결된 노트

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