Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 5-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 1-(3-Chlorophenyl)propan-2-one | HCID 2734097 | — |
| 반응물 | (4-(Benzyloxy)phenyl)hydrazine monohydrochloride | HCID 3016725 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole | HCID 20529201 | — |
반응 단계
An amount of 11.7 g (47 m mole) of 4-benzyloxyphenylhydrazine-hydrochloride and 6.39 g (38 m mole) of (3-chlorophenyl)-acetone was dissolved in 35 ml of absolute ethanol, and after addition of 2.7 ml of concentrated sulfuric acid the mixture was refluxed for five hours. After the ethanol was distilled off, the residue was mixed with water and extracted with chloroform. The extracts were dried over sodium sulfate and evaporated. The evaporation residue was purified by chromatography on silicagel by using toluene as solvent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343811 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-f34ce889d3be4b0e8cb3c4cfd7a91c36 |
| 출처 메모 | uspto-grants-1982_08 |