2-Bromopropiophenone → 5Benzyloxy-3-methyl-2-phenyl-1H-indole

HRID 66822

반응식

HRID 66822 반응식
Br[CH:2]([CH3:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[CH2:12]([O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(N(CC)CC)C>[CH2:12]([O:19][C:20]1[CH:21]=[C:22]2[C:23](=[CH:25][CH:26]=1)[NH:24][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[C:2]2[CH3:11])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 164522-BromopropiophenoneHCID 228604-Benzyloxyaniline

생성물 1

HCID 218823405Benzyloxy-3-methyl-2-phenyl-1H-indole

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

An amount of 3.6 g (0.015 mole) of 2-bromo-propiophenone and 6 g (0.03 mole) of 4-benzyloxy-aniline were refluxed for two hours in 15 ml of triethylamine. The mixture was evaporated to dryness, and the residue was heated for two hours to 180° C. After cooling, the residue was mixed with 10% hydrochloric acid and extracted with chloroform. The extracts were dried over sodium sulfate, filtered, and evaporated. The residue obtained was purified by column chromatography on silicagel with toluene as solvent.

후처리

  1. customThe mixture was evaporated to dryness
  2. temperaturethe residue was heated for two hours to 180° C
  3. temperatureAfter cooling
  4. additionthe residue was mixed with 10% hydrochloric acid
  5. extractionextracted with chloroform
  6. dry with materialThe extracts were dried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated
  9. customThe residue obtained
  10. customwas purified by column chromatography on silicagel with toluene as solvent

출처 및 근거

ORD 기록
ord-99133378138d4a53a7c17c71f1a63b52
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343811

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