Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenethylpiperazine → (1h-Indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenethylpiperazine | HCID 79214 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Chloro-1-methylpyridinium iodide | HCID 167069 | — |
| 반응물 | Indole-4-carboxylic acid | HCID 595229 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | (1h-Indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride | HCID 131725875 | 100.1% |
반응 단계
A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084143B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-d902f388819647f19c93534fd4a3ba09 |
| 출처 메모 | uspto-grants-2006_08 |