1-Phenethylpiperazine → (1h-Indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride

HRID 6686

반응식

HRID 6686 반응식
[C:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2)([OH:3])=O.[I-].[Cl:14]C1C=CC=C[N+]=1C.[CH2:22]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(N(C(C)C)C(C)C)C>CN1CCCC1=O.CC(C)=O>[ClH:14].[NH:8]1[C:9]2[C:5](=[C:4]([C:1]([N:33]3[CH2:34][CH2:35][N:30]([CH2:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:31][CH2:32]3)=[O:3])[CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7]1

참가 물질

7

반응물 4

HCID 792141-PhenethylpiperazineHCID 81531DiisopropylethylamineHCID 1670692-Chloro-1-methylpyridinium iodideHCID 595229Indole-4-carboxylic acid

생성물 1

HCID 131725875(1h-Indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride수율 100.1%

시약·촉매·용매 2

HCID 180Acetone용매HCID 13387N-methyl-2-pyrrolidone용매2회

실험 절차

A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.

후처리

  1. customthe crude product is obtained
  2. customthe hydrochloride is precipitated
  3. customAfter drying

출처 및 근거

ORD 기록
ord-d902f388819647f19c93534fd4a3ba09
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084143B2

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