Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-[3-(4-Methoxy-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methylpropanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-2-methylpropanoic acid | HCID 74924 | — |
| 반응물 | 3-(4-methoxyphenyl)-2-methyl-1-propyl-1H-indole-5-ol | HCID 20529189 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-[3-(4-Methoxy-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methylpropanoic acid | HCID 20529081 | — |
반응 단계
A mixture of 5.9 g (0.02 mole) of 3-(4-methoxyphenyl)-2-methyl-1-propyl-1H-indole-5-ol, 5.1 g (0.03 mole) of 2-bromo-2-methyl-propanoic acid, and 15 g of potassium carbonate was refluxed in 100 ml of acetone for 48 hours. The acetone was removed in vacuo, and the residue was acidified with 2N hydrochloric acid. After extraction with ethyl acetate, the extracts were dried over sodium sulfate and evaporated. The residue obtained was purified by chromatography on silicagel (eluant: chloroform/methanol (9:1)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343811 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-acfe4b0ec0cf4652b3bbfe920251e012 |
| 출처 메모 | uspto-grants-1982_08 |