Potassium Carbonate → 2-[3-(4-Methoxy-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methylpropanoic acid

HRID 66889

반응식

HRID 66889 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]([CH2:19][CH2:20][CH3:21])[C:10]=2[CH3:22])=[CH:5][CH:4]=1.Br[C:24]([CH3:29])([CH3:28])[C:25]([OH:27])=[O:26].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][C:24]([CH3:29])([CH3:28])[C:25]([OH:27])=[O:26])[CH:16]=3)[N:11]([CH2:19][CH2:20][CH3:21])[C:10]=2[CH3:22])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 749242-Bromo-2-methylpropanoic acidHCID 205291893-(4-methoxyphenyl)-2-methyl-1-propyl-1H-indole-5-ol

생성물 1

HCID 205290812-[3-(4-Methoxy-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methylpropanoic acid

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 5.9 g (0.02 mole) of 3-(4-methoxyphenyl)-2-methyl-1-propyl-1H-indole-5-ol, 5.1 g (0.03 mole) of 2-bromo-2-methyl-propanoic acid, and 15 g of potassium carbonate was refluxed in 100 ml of acetone for 48 hours. The acetone was removed in vacuo, and the residue was acidified with 2N hydrochloric acid. After extraction with ethyl acetate, the extracts were dried over sodium sulfate and evaporated. The residue obtained was purified by chromatography on silicagel (eluant: chloroform/methanol (9:1)).

후처리

  1. customThe acetone was removed in vacuo
  2. extractionAfter extraction with ethyl acetate
  3. dry with materialthe extracts were dried over sodium sulfate
  4. customevaporated
  5. customThe residue obtained
  6. customwas purified by chromatography on silicagel (eluant: chloroform/methanol (9:1))

출처 및 근거

ORD 기록
ord-acfe4b0ec0cf4652b3bbfe920251e012
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343811

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