Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 2-Bis(p-dimethylaminophenyl)Methoxy Acetanilide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Dimethyl Ether | HCID 8254 | — |
| 반응물 | 4,4'-Bis(dimethylamino)benzhydrol | HCID 92742 | — |
| 반응물 | 2-Hydroxy-N-phenylacetamide | HCID 264260 | — |
| 촉매 | Methanesulfonic Acid | HCID 6395 | — |
| 촉매 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 2-Bis(p-dimethylaminophenyl)Methoxy Acetanilide | HCID 20488041 | — |
반응 단계
A solution of alpha-hydroxyacetanilide (3.62 g, 0.024 mole), 4,4'-bis(N,N-dimethylamino)benzhydrol, methyl ether (6.81 g, 0.024 mole) 50 ml of tetrahydrofuran, 153 ml of n-hexane, and one drop of methanesulfonic acid was refluxed for 11 hours, during which time an additional 300 ml of solvent was added. The blue-green solution was decolorized with 4 drops of tetramethylguanidine and the reaction mixture was filtered hot and the filtrate chilled. Yellow-green crystals formed, which were recrystallized from 30 ml petroleum ether/15 ml acetone to give a white solid, mp 118°-128° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343939 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-a51f038435e34d9bbc72f79b2f35dec5 |
| 출처 메모 | uspto-grants-1982_08 |