Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 4-[[Bis(p-dimethylaminophenyl)methoxy]acetyl]Morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Dimethyl Ether | HCID 8254 | — |
| 반응물 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 반응물 | 4,4'-Bis(dimethylamino)benzhydrol | HCID 92742 | — |
| 촉매 | Methanesulfonic Acid | HCID 6395 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 4-[[Bis(p-dimethylaminophenyl)methoxy]acetyl]Morpholine | HCID 20488036 | — |
반응 단계
A solution of 4,4'-bis(N,N-dimethylamino)benzhydrol, methyl ether (9.0 g, 0.032 mole), glycol morpholinamide (4.6 g, 0.032 mole), 150 ml of tetrahydrofuran, 250 ml of n-hexane and 4 drops of methanesulfonic acid was refluxed for about 8 hours, during which time an additional 200 ml of solvent was added. The volume was reduced to 200 ml and the color was discharged with tetramethylguanidine. The solution was filtered hot and then cooled to precipitate a white solid. The solid was recrystallized from 350 ml of methyl cyclohexane to give 4.9 g of blue crystals; mp 147.8°-150° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343939 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-aedb3f7bf82141bca0c692617ca9a875 |
| 출처 메모 | uspto-grants-1982_08 |