Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 6-(p-Chlorophenyl)coumarin-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 4'-Chloro-4-biphenylol | HCID 91589 | — |
| 반응물 | 2,2-Diethylpropanedioate | HCID 6951563 | — |
| 반응물 | 4'-Chloro-4-hydroxy[1,1'-biphenyl]-3-carbaldehyde | HCID 20099791 | — |
| 생성물 | 6-(p-Chlorophenyl)coumarin-3-carboxylic acid | HCID 20529781 | — |
반응 단계
4-(p-Chlorophenyl)phenol is converted via the Duff reaction [J. Chem. Soc., 547 (1941)] to 2-hydroxy-5-(p-chlorophenyl)benzaldehyde, mp. 74°-78° C. i.r. 6.02μ. A solution of 2]3 mg. (1 mmole) of this aldehyde, 0.4 ml. (2.63 mmole) of diethylmalonate and 0.2 ml. (2 mmole) of piperidine is heated for 10 minutes and kept at 25° C. for 2 hours. Then 5 ml. of 9 N HCl is added and the mixture stirred at reflux overnight. The mixture is cooled in an ice bath and filtered to yield 238 mg. of the desired compound, i.r. 5.74, 5.9μ.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343938 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-4cacc45e26214cf3858809b96f7c81c9 |
| 출처 메모 | uspto-grants-1982_08 |