Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 2-Methylbenzoyl chloride | HCID 70276 | — |
| 반응물 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041514 | 35.1% |
반응 단계
A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 2-toluoyl chloride in 250 ml xylene was heated at reflux for 20 hours. The reaction mixture was cooled to room temperature and the resulting precipitate removed by filtration. Following recrystallization for toluene, 11.8 g (35% yield) of pure product was otained; m.p. 170° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343945 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-40e39dbc987749c18435765ac008b42e |
| 출처 메모 | uspto-grants-1982_08 |