Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methylbenzoyl chloride → 5-(3-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methylbenzoyl chloride | HCID 74375 | — |
| 반응물 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 5-(3-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041515 | 12% |
반응 단계
A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 3-toluoyl chloride in 250 ml xylene was heated at reflux for 20 hours. The reaction mixture was cooled to room temperature and the resulting precipitate removed by filtration. The crude product was washed with petroleum ether and then recrystallized twice from toluene to obtain 4.0 g (12% yield) of pure product; m.p. 142° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343945 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-0ee1bf474793456ab285a40aa7291cc3 |
| 출처 메모 | uspto-grants-1982_08 |