Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylbenzoyl Chloride → 5-(4-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylbenzoyl Chloride | HCID 13405 | — |
| 반응물 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-(4-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041516 | — |
반응 단계
A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 8.0 g (0.05 mole) 4-toluoyl chloride in 250 ml toluene was heated at reflux for 20 hours. Unreacted amino compound was removed by cooling the reaction mixture and filtering the precipitate. Concentration of the filtrate in vacuo gave the crude product, which was purified by recrystallization from cyclohexane. Yield was 9.1 g (27%); m.p. 127° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343945 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-941fe4c55371425b876f0a5cbd9052c1 |
| 출처 메모 | uspto-grants-1982_08 |