Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Anisoyl chloride → 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Anisoyl chloride | HCID 7477 | — |
| 반응물 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041517 | — |
반응 단계
A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.8 g (0.08 mole) 4-anisoyl chloride in 200 ml xylene was heated at reflux for 20 hours. Cooling of the reaction mixture resulted in precipitation of the crude product, which was then isolated by filtration. Purification was achieved by washing the crude product with hot hexane. Yield was 12.0 g (82%); m.p. 172° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343945 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-c5e879964bea48bfb1cb9bbca35b987c |
| 출처 메모 | uspto-grants-1982_08 |