Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride, 3-nitro- → 5-(3-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| 반응물 | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 5-(3-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041518 | 69.1% |
반응 단계
A solution of 21.8 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 18.6 g (0.1 mole) 3-nitrobenzoyl chloride in 250 ml xylene was heated at reflux for 20 hours. Unreacted starting amino compound was recovered by cooling the reaction mixture and filtering the resulting precipitate. The filtrate was concentrated in vacuo and the residue recrystallized from xylene. After washing with petroleum ether, 25.4 g (69% yield) of pure product was obtained; m.p. 198° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343945 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-de6e7a9e35cd4ea48025e0a704ebed64 |
| 출처 메모 | uspto-grants-1982_08 |