4-Nitrobenzoyl chloride → 5-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66940노트

반응식

HRID 66940 반응식
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[N+:11]([C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][CH:15]=1)([O-:13])=[O:12]>C1(C)C=CC=CC=1>[N+:11]([C:14]1[CH:15]=[CH:16][C:17]([C:18]([NH:1][C:2]2[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=2)=[O:19])=[CH:21][CH:22]=1)([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 85024-Nitrobenzoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

생성물 1

HCID 130415195-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole수율 73.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 10.2 g (0.055 mole) 4-nitrobenzoyl chloride in 200 ml toluene was heated at reflux for 20 hours. Upon cooling to room temperature, the crude product precipitated from the reaction mixture and was isolated by filtration. After washing with hexane, 13.5 g (73% yield) of pure product was obtained; m.p. 214° C.

후처리

  1. temperatureat reflux for 20 hours
  2. customthe crude product precipitated from the reaction mixture
  3. customwas isolated by filtration
  4. washAfter washing with hexane

출처 및 근거

ORD 기록
ord-cf535115d4a34be684be0052ae84a514
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343945

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