Water → 4-(4-(methylsulfonyl)phenyl)-N-(tetrahydro-2H-pyran-4-yl)-6-(trifluoromethyl)pyrimidin-2-amine

HRID 6696

반응식

HRID 6696 반응식
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=1)(=O)=O.[O:25]1[CH2:30][CH2:29][CH:28]([NH2:31])[CH2:27][CH2:26]1.O>CN1CCCC1=O>[CH3:20][S:17]([C:14]1[CH:15]=[CH:16][C:11]([C:9]2[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=[C:5]([NH:31][CH:28]3[CH2:29][CH2:30][O:25][CH2:26][CH2:27]3)[N:10]=2)=[CH:12][CH:13]=1)(=[O:19])=[O:18]

참가 물질

5

반응물 3

HCID 962WaterHCID 4192234-AminotetrahydropyranHCID 111764432-(Methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine

생성물 1

HCID 98223574-(4-(methylsulfonyl)phenyl)-N-(tetrahydro-2H-pyran-4-yl)-6-(trifluoromethyl)pyrimidin-2-amine수율 40%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

To a solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (0.277 g, 0.73 mmol) in N-methylpyrrolidone (1.25 ml) was added tetrahydro-2H-pyran-4-amine (0.147 g, 2 eq.), the mixture was stirred for 1 hour and then water (1.25 ml) was added dropwise. This resulted in a precipitate being formed, which was collected by filtration, and dried in vacuo (0.258 g). This material was then purified by autopurification to give the title compound as a colourless solid (0.116 g, 40%).

후처리

  1. customThis resulted in a precipitate
  2. custombeing formed
  3. filtrationwhich was collected by filtration
  4. customdried in vacuo (0.258 g)
  5. customThis material was then purified by autopurification

출처 및 근거

ORD 기록
ord-17ed47ef835b4d92b99869f4520b7108
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084148B2

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