Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(3-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Bromo-3'-chloroacetophenone | HCID 38738 | — |
| 반응물 | 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one hydrochloride | HCID 18321355 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(3-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine | HCID 12797992 | 50.4% |
반응 단계
In this example, 2.67 g of 4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine mono-hydrochloride, 2.33 g of α-bromo-m-chloroacetophenone, 2.8 ml of triethylamine and 30 ml of methanol are mixed and stirred at room temperature overnight. Then, the white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 2.89 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 1.93 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04344948 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-1f54b4acf24a4bcbaa663e740ddf1acb |
| 출처 메모 | uspto-grants-1982_08 |