Diethylamine → 2-(Diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole

HRID 67105

반응식

HRID 67105 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[S:7][C:8]2[C:9](=[CH:11][C:12]3[N:13]=[C:14]([NH2:18])[S:15][C:16]=3[CH:17]=2)[N:10]=1)=[O:4].[CH2:19]([NH:21][CH2:22][CH3:23])[CH3:20]>O1CCOCC1>[CH2:19]([N:21]([N:5]([C:3](=[O:4])[CH3:2])[C:6]1[S:7][C:8]2[C:9](=[CH:11][C:12]3[N:13]=[C:14]([NH2:18])[S:15][C:16]=3[CH:17]=2)[N:10]=1)[CH2:22][CH3:23])[CH3:20]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 205282012-Chloroacetylamino-6-amino-benzo[1,2-d:5,4-d']bisthiazole

생성물 1

HCID 867385292-(Diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 0.5 gm of 2-(chloroacetyl-amino)-6-amino-benzo[1,2-d:5,4-d']bisthiazole, 0.7 gm of diethylamine and 3 ml of dioxane was refluxed for 2 hours. Then, the solvent was evaporated in vacuo, the residue was dissolved in ethyl acetate, and the solution was washed with water and dried over sodium sulfate. After evaporation of the solvent, 0.3 gm (60% of theory) of the title compound, M.P. 203°-205° C. (from ethanol/dimethylformamide) were obtained.

후처리

  1. temperaturewas refluxed for 2 hours
  2. customThen, the solvent was evaporated in vacuo
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washthe solution was washed with water
  5. dry with materialdried over sodium sulfate
  6. customAfter evaporation of the solvent, 0.3 gm (60% of theory) of the title compound
  7. customM.P. 203°-205° C. (from ethanol/dimethylformamide) were obtained

출처 및 근거

ORD 기록
ord-cce5813548c3422aa236ff55eaeacd1a
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04344946

연결된 노트

불러오는 중…