Potassium Hydroxide → 3-(4-Biphenylyl)-2-butenoic acid

HRID 67138

반응식

HRID 67138 반응식
C([O:3][C:4](=[O:20])[CH:5]=[C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)[CH3:7])C.[OH-].[K+]>C(O)C>[C:11]1([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:12]=[CH:13][C:8]([C:6]([CH3:7])=[CH:5][C:4]([OH:20])=[O:3])=[CH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 545016723-(4-Biphenylyl)-2-butenoic acid ethyl ester

생성물 1

HCID 2967533-(4-Biphenylyl)-2-butenoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The product resulting from (a), above, is mixed with 6 g of 85% potassium hydroxide in 100 ml of aqueous ethanol and the resulting mixture heated on a steam bath for 30 minutes. The mixture is then cooled, poured into ice and extracted thrice with 25 ml portions of diethylether. The aqueous phase is filtered over Celite and the filtrate acidified with 2 N hydrochloric acid to pH 4 and cooled. The resulting precipitate is filtered, washed with ether, air dried with suction and then dried under high vacuum at 50° C. to yield the heading compound, substantially in trans form.

후처리

  1. temperaturethe resulting mixture heated on a steam bath for 30 minutes
  2. temperatureThe mixture is then cooled
  3. additionpoured into ice
  4. extractionextracted thrice with 25 ml portions of diethylether
  5. filtrationThe aqueous phase is filtered over Celite
  6. temperaturecooled
  7. filtrationThe resulting precipitate is filtered
  8. washwashed with ether, air
  9. customdried with suction
  10. customdried under high vacuum at 50° C.
  11. customto yield the heading compound

출처 및 근거

ORD 기록
ord-adad65625ed443a585f437e7219331b8
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04344966

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