Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-[(6-Chloropyridazin-3-yl)oxy]aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3,6-Dichloropyridazine | HCID 67331 | — |
| 반응물 | 4-Amino-2-chlorophenol | HCID 77578 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 4-[(6-Chloropyridazin-3-yl)oxy]aniline | HCID 10680523 | — |
반응 단계
12 g of sodium hydride was added in portions to a stirred solution of 71.8 g of 1A and 25 g of 3,6-dichloropyridazine in 300 ml of dimethyl sulfoxide, the temperature of the mixture being held at 50° C. The mixture then was stirred for one hour and poured into ice water. The mixture was slightly acidified with dilute hydrochloric acid, and was extracted with methylene chloride. The extract was washed with water, dried (magnesium sulfate) and the solvent was evaporated to give 4-(6-chloro-3-pyridazinyloxy)benzeneamine (1B), as a tan solid, mp: 126°-129° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04345076 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-3c0a74c576584da0a7ede398eec0b46b |
| 출처 메모 | uspto-grants-1982_08 |