Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 4-(6-Chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3,6-Dichloropyridazine | HCID 67331 | — |
| 반응물 | 4-Amino-2,5-dimethylphenol | HCID 76544 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 4-(6-Chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine | HCID 13050844 | — |
반응 단계
4.8 g of sodium hydride was added in portions to a stirred solution of 30 g of 3,6-dichloropyridazine and 27.4 g of 4-amino-2,5-dimethylphenol in 300 ml of dimethyl sulfoxide. The temperature of the mixture rose to 65° C. The mixture was then stirred for 18 hours at room temperature, poured over ice water and filtered. Recrystallization of the filter cake from methanol gave 4-(6-chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine, as a brown solid (5A), mp: 138°-140° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04345076 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-d7f16098e6ce4f10a35106a753a04e7c |
| 출처 메모 | uspto-grants-1982_08 |