2-Bromo-1,2-diphenylethan-1-one → 2,3,5,6,7,8-Hexahydro-2,3-diphenylthiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide

HRID 67230

반응식

HRID 67230 반응식
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][NH:3][C:2]1=[S:8].[Br:9][CH:10]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12]>CC(C)=O>[BrH:9].[C:19]1([CH:10]2[S:8][C:2]3=[N:3][CH2:4][CH2:5][CH2:6][CH2:7][N:1]3[C:11]2([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[OH:12])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

4

반응물 2

HCID 1026302-Bromo-1,2-diphenylethan-1-oneHCID 7365891,3-Diazepane-2-thione

생성물 1

HCID 205282882,3,5,6,7,8-Hexahydro-2,3-diphenylthiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A 2.6 g. portion of hexahydro-2H-1,3-diazepin-2-thione is dissolved in 150 ml. of acetone and clarified. A 5.5 g. portion of 2-bromo-2-phenylacetophenone is added and the solution is refluxed for one hour and then stirred at room temperature for 16 hours. The solid is collected, washed with acetone and dried in vacuo at 60° C., giving 6.5 g. of the desired product, m.p. 195°-197° C. (dec.).

후처리

  1. temperaturethe solution is refluxed for one hour
  2. customThe solid is collected
  3. washwashed with acetone
  4. customdried in vacuo at 60° C.
  5. customgiving 6.5 g

출처 및 근거

ORD 기록
ord-a3c634d5fec74401a80367e4f62dcb78
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04344954

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