참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Ro 14-7437 | HCID 127597 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | HCID 20518108 | HCID 20518108 | — |
반응 단계
A mixture of 1.42 g (5 mmol) of ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate, 100 mg of potassium cyanide and 10 ml of ethyleneglycol is stirred at 130° C. for 6 hours, subsequently diluted with chloroform, washed with water, dried over magnesium sulphate and evaporated. After recrystallisation of the residue from ethyl acetate, there is obtained 2-hydroxyethyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate of melting point 222°-223° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04346030 |
|---|
| 출처 데이터셋 | uspto-grants-1982_08 |
|---|
| ORD ID | ord-c189917d6745426ea292015eab11fd14 |
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| 출처 메모 | uspto-grants-1982_08 |
|---|
