4-(Aminomethyl)Benzoic Acid → [4-(Aminomethyl)phenyl]methanol

HRID 6734

반응식

HRID 6734 반응식
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([CH2:7][OH:8])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 655264-(Aminomethyl)Benzoic AcidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 6496943[4-(Aminomethyl)phenyl]methanol수율 82.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 4-aminomethyl-benzoic acid (0.20 g) in 20 mL diethyl ether was cooled to 0° C. Lithium aluminum hydride (0.19 g) was added in portions to the stirring carboxylic acid solution. The resulting slurry was stirred for 20 h and then cooled to 0 C. The mixture was carefully quenched by the sequential addition of 0.2 mL of water followed by 0.2 mL of 3 N sodium hydroxide followed by 0.6 mL of more water. The mixture was stirred for 15 min, then filtered to remove the aluminum salts. The filtrate was collected and the volatile material was evaporated to give 150 mg of (4-aminomethyl-phenyl)-methanol.

후처리

  1. temperaturecooled to 0 C
  2. customThe mixture was carefully quenched by the sequential addition of 0.2 mL of water
  3. stirringThe mixture was stirred for 15 min
  4. filtrationfiltered
  5. customto remove the aluminum salts
  6. customThe filtrate was collected
  7. customthe volatile material was evaporated

출처 및 근거

ORD 기록
ord-05979e650a604461bc29aa3be1d9d2c3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084154B2

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