참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sarcosine | HCID 1088 | — |
| 반응물 | 5-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 10487522 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 3,4-dihydro-4,6-dimethyl-2H-1,4-benzodiazepine-2,5(1H)-dione | HCID 21708975 | — |
반응 단계
A mixture of 14.0 g (79 mmol) of 6-methylisatoic acid anhydride, 7.04 g (79 mmol) of sarcosine and 80 ml of dimethyl sulphoxide is stirred at 110° C. for 3 hours. The red coloured solution is evaporated in a high vacuum. The residue is treated with 80 ml of ethanol, the product crystallising out. There is obtained 3,4-dihydro-4,6-dimethyl-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 200°-202° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04346031 |
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| 출처 데이터셋 | uspto-grants-1982_08 |
|---|
| ORD ID | ord-3182e92f9292405e8150e0d2d9c7d3f1 |
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| 출처 메모 | uspto-grants-1982_08 |
|---|
