Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Ethanol, 1-ethoxy-2,2,2-trifluoro- | HCID 9897 | — |
| 반응물 | Serotonin Hydrochloride | HCID 160436 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride | HCID 22018500 | — |
반응 단계
A mixture of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (0.5 g), trifluoroacetaldehyde ethyl hemiacetal (0.35 mL), acetic acid (0.32 mL) and ethanol (22.5 mL) was heated at reflux for 16 h. The solvent and excess reagents were evaporated to dryness under vacuum. The residue was washed with diethyl ether to afford 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol hydrochloride (0.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084154B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-600460d8babf4f8aadae29babece78a3 |
| 출처 메모 | uspto-grants-2006_08 |