Acetic Acid → 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride

HRID 6741

반응식

HRID 6741 반응식
[ClH:1].[NH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[NH:7][CH:6]=1.C(O[CH:18](O)[C:19]([F:22])([F:21])[F:20])C.C(O)(=O)C>C(O)C>[ClH:1].[F:20][C:19]([F:22])([F:21])[CH:18]1[C:6]2[NH:7][C:8]3[C:13](=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=3)[C:5]=2[CH2:4][CH2:3][NH:2]1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 9897Ethanol, 1-ethoxy-2,2,2-trifluoro-HCID 160436Serotonin Hydrochloride

생성물 1

HCID 220185001-trifluoromethyl-2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (0.5 g), trifluoroacetaldehyde ethyl hemiacetal (0.35 mL), acetic acid (0.32 mL) and ethanol (22.5 mL) was heated at reflux for 16 h. The solvent and excess reagents were evaporated to dryness under vacuum. The residue was washed with diethyl ether to afford 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol hydrochloride (0.5 g).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 h
  3. customThe solvent and excess reagents were evaporated to dryness under vacuum
  4. washThe residue was washed with diethyl ether

출처 및 근거

ORD 기록
ord-600460d8babf4f8aadae29babece78a3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084154B2

연결된 노트

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