참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sarcosine | HCID 1088 | — |
| 반응물 | 5-Fluoroisatoic anhydride | HCID 288560 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 3,4-Dihydro-7-fluoro-4-methyl-1H-1,4-benzodiazepine-2,5-dione | HCID 658990 | — |
반응 단계
24 g (132.5 mmol) of 5-fluoroisatoic acid anhydride are dissolved in 140 ml of dimethyl sulphoxide and treated with 11.8 g (132.5 mmol) of sarcosine. The solution is stirred at 100° C. until the gas evolution ceases (duration: ca 1.5 hours) and subsequently poured into ca 1.2 liters of water. After stirring for 10 minutes, a solid crystallises out. The crystals are filtered off under suction, washed with 1 liter of water and dried. There is obtained 7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 262°-263° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04346033 |
|---|
| 출처 데이터셋 | uspto-grants-1982_08 |
|---|
| ORD ID | ord-0af1d5f9b7f04271b680a54ce4c4cb7b |
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| 출처 메모 | uspto-grants-1982_08 |
|---|
