Methylamine → 7-Methylaminosulfonyl-1,2,3,4-tetrahydro-isoquinoline hydrochloride

HRID 6760

반응식

HRID 6760 반응식
[CH3:1][NH2:2].C([N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][C:10]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:11][CH:12]=2)[CH2:7]1)(=O)C>CO>[ClH:19].[CH3:1][NH:2][S:16]([C:10]1[CH:9]=[C:8]2[C:13]([CH2:14][CH2:15][NH:6][CH2:7]2)=[CH:12][CH:11]=1)(=[O:18])=[O:17]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 126069042-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

생성물 1

HCID 220184947-Methylaminosulfonyl-1,2,3,4-tetrahydro-isoquinoline hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methylamine in methanol (2 M, 20 mL) was added to 2-acetyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride (2 g). The mixture was stirred at rt for 16 h. Excess methylamine and methanol were evaporated under vacuum and hydrochloric acid (10%, 30 mL) was added to the residue. The mixture was heated at reflux for 3 h and the aqueous solution was evaporated under vacuum. The residue was trituiated with ethyl acetate (2×20 mL) to afford 7-methylaminosulfonyl-1,2,3,4-tetrahydro-isoquinoline hydrochloride (1.9 g).

후처리

  1. customExcess methylamine and methanol were evaporated under vacuum and hydrochloric acid (10%, 30 mL)
  2. additionwas added to the residue
  3. temperatureThe mixture was heated
  4. temperatureat reflux for 3 h
  5. customthe aqueous solution was evaporated under vacuum

출처 및 근거

ORD 기록
ord-4fa4e9c4bf0048689c33242d888f1867
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084154B2

연결된 노트

불러오는 중…