2-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylideneacetic Acid → 2-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylacetic Acid

HRID 67640

반응식

HRID 67640 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[C:6](=[CH:15][C:16]([OH:18])=[O:17])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9][CH2:10][C:4]=2[CH:3]=1>C(O)C.[Na].[Hg]>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[CH:6]([CH2:15][C:16]([OH:18])=[O:17])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9][CH2:10][C:4]=2[CH:3]=1

참가 물질

4

반응물 1

HCID 538262432-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylideneacetic Acid

생성물 1

HCID 205274972-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylacetic Acid

시약·촉매·용매 2

HCID 9837419Sodium amalgam촉매HCID 702Ethanol용매

실험 절차

A solution of 2-chloro-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-ylideneacetic acid (23.5 g, described in Example 1) in ethanol (100 ml, hot) is added to 5% sodium amalgam (100 g). The mixture is stirred at 60°-70° C. for 3 hr and decanted. The solution is evaporated of half its original volume, acidified with conc. hydrochloric acid and extracted with chloroform. The organic extract is dried and evaporated. The residue is crystallized from diethyl ether-hexane to give the title compound as crystals, mp 142°-146° C.

후처리

  1. customdecanted
  2. customThe solution is evaporated of half its original volume
  3. extractionextracted with chloroform
  4. extractionThe organic extract
  5. customis dried
  6. customevaporated
  7. customThe residue is crystallized from diethyl ether-hexane

출처 및 근거

ORD 기록
ord-c37440869afb46ca9a86a45406a02ba3
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04346090

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