Water → 4-(4-Chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenylimino)-3-methyl-4-thiazoline

HRID 67753노트

반응식

HRID 67753 반응식
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2(O)[CH2:13][S:12][C:11](=[N:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[N:10]2[CH3:22])=[CH:5][C:4]=1[S:24](=[O:29])(=[O:28])[N:25]([CH3:27])[CH3:26].O>CO.C(N(CC)CC)C>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH3:22])[C:11](=[N:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[S:12][CH:13]=2)=[CH:5][C:4]=1[S:24](=[O:29])(=[O:28])[N:25]([CH3:26])[CH3:27]

참가 물질

5

반응물 2

HCID 962WaterHCID 705316964-(4-Chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenyl-imino)-3-methylthiazolidin-4-ol hydrobromide

생성물 1

HCID 205271334-(4-Chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenylimino)-3-methyl-4-thiazoline

시약·촉매·용매 2

HCID 887Methanol용매HCID 8471Triethylamine용매

실험 절차

10.8 g of 4-(4-chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenyl-imino)-3-methylthiazolidin-4-ol hydrobromide are heated at the boil in a mixture of 100 ml of methanol and 10 ml of triethylamine for 30 minutes and the reaction mixture is then poured into an equal volume of water. The resulting mixture is stirred for about 2 hours at room temperature and the crystals are filtered off and recrystallized from ethanol. Melting point 153°-156° C.

후처리

  1. filtrationthe crystals are filtered off
  2. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-09a63501d0e54ad08018f34b9ad20fe8
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04346088

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