Water → 7-Phenyl-1H-indene

HRID 67814노트

반응식

HRID 67814 반응식
[C:1]1([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][CH2:10][CH:11]3O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1C=CC=CC=1>[C:1]1([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][CH:10]=[CH:11]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 129423854-Phenyl-2,3-dihydro-1H-inden-1-ol

생성물 1

HCID 129423867-Phenyl-1H-indene수율 96.2%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A stirred solution of 16.7 g (0.08 mole) of 4-phenyl-1-indanol and 0.1 g of p-toluenesulfonic acid in 180 ml of benzene was heated under reflux for one hour as by-product water was collected in a Dean-Stark trap. The reaction mixture was washed with two portions of 50 ml of a 5% aqueous solution of sodium bicarbonate, then with one portion of 50 ml of water. The organic phase was dried with magnesium sulfate, filtered, and the filtrate concentrated under reduced pressure, keeping the temperature under 50° C., to give 14.8 g of 7-phenyl-1H-indene. The nmr spectrum was consistent with the proposed structure.

후처리

  1. customwas collected in a Dean-Stark trap
  2. washThe reaction mixture was washed with two portions of 50 ml of a 5% aqueous solution of sodium bicarbonate
  3. dry with materialThe organic phase was dried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationthe filtrate concentrated under reduced pressure
  6. customunder 50° C.

출처 및 근거

ORD 기록
ord-750c27f0eb97440e9edc04a17018fbae
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04346251

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