Cysteamine → 6-Methyl-3-pyridylmethyl-4-pyrimidone
반응식
C[N:2]([CH2:4][C:5]1O[C:8]([CH2:10]O)=[CH:7][CH:6]=1)[CH3:3].CN(CC1[O:20]C(CSCCN)=CC=1)C.NCCS.[NH2:30][CH2:31][CH2:32][C:33]1[N:37]=CN[CH:34]=1.[H][H]>C(O)(=O)C>[CH3:34][C:33]1[N:37]=[C:10]([CH2:8][C:7]2[CH:3]=[N:2][CH:4]=[CH:5][CH:6]=2)[NH:30][C:31](=[O:20])[CH:32]=1참가 물질
6
실험 절차
5-Dimethylaminomethyl-2-furanmethanol can be converted into 2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamine by heating under reflux in acetic acid with cysteamine and can be further converted into various histamine H2 -antagonists for example, by reacting with a substituted pyrimidone to give 2-2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino-5-(6-methyl-3-pyridylmethyl-4-pyrimidone by methods described in EP 3677.
후처리
- temperatureby heating
출처 및 근거
- ORD 기록
- ord-3bde087f247843d19e16bfe9b8309d82
- 출처 데이터셋
- uspto-grants-1982_08
- 특허 번호
- US04347191
반응 노트
불러오는 중…