Piperidine → HCID 2804025, 화합물

HRID 6793노트

반응식

HRID 6793 반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15]Br)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 11430Potassium CarbonateHCID 2779977HCID 2779977, 화합물

생성물 1

HCID 2804025HCID 2804025, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 1-(3,5-bistrifluoromethylphenyl)-3-bromoprop-1-yne (2.53 g), piperidine (5 ml) and anhydrous potassium carbonate (5 g) in dry acetone (50 ml) was heated at reflux with stirring for 18 h. Removal of the solvent under reduced pressure and distillation of the residue under reduced pressure gave 2.26 g of an oil of boiling point 95° C./0.025 mm Hg.

후처리

  1. temperaturewas heated
  2. temperatureat reflux
  3. customRemoval of the solvent
  4. distillationunder reduced pressure and distillation of the residue under reduced pressure

출처 및 근거

ORD 기록
ord-02f0b0daf7f34f13804f67028ba672a7
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084158B2

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