3,5-Difluorobenzyl chloride → [6-Chloro-1-(3,5-difluoro-benzyl)-1H-indol-3-yl]-[4-(2-methoxy-phenyl)-piperidin-1-yl]-methanone

반응식

[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][CH:16]([c:19]4[c:20]([O:25][CH3:26])[cH:21][cH:22][cH:23][cH:24]4)[CH2:17][CH2:18]3)[cH:7][nH:8][c:9]2[cH:10]1.[Cl:27][CH2:28][c:29]1[cH:30][c:31]([F:36])[cH:32][c:33]([F:35])[cH:34]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][CH:16]([c:19]4[c:20]([O:25][CH3:26])[cH:21][cH:22][cH:23][cH:24]4)[CH2:17][CH2:18]3)[cH:7][n:8]([CH2:28][c:29]3[cH:30][c:31]([F:36])[cH:32][c:33]([F:35])[cH:34]3)[c:9]2[cH:10]1

참가 물질

반응물 2

HCID 27369553,5-Difluorobenzyl chloride

HCID 59429632(6-Chloro-1H-indol-3-yl)[4-(2-methoxyphenyl)piperidin-1-yl]methanone

생성물 1

HCID 16062435[6-Chloro-1-(3,5-difluoro-benzyl)-1H-indol-3-yl]-[4-(2-methoxy-phenyl)-piperidin-1-yl]-methanone

출처 및 근거

ORD 기록: ord-7a94b5658ec744e68c25ccc6c549f831
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

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