6-Nitro-2-piperidin-1-ylquinoline → 2-Piperidin-1-ylquinolin-6-amine

HRID 6796

반응식

HRID 6796 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[CH:8]=[CH:7]2)([O-])=O>CO.[OH-].[OH-].[Pd+2]>[N:14]1([C:9]2[CH:8]=[CH:7][C:6]3[C:11](=[CH:12][CH:13]=[C:4]([NH2:1])[CH:5]=3)[N:10]=2)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

참가 물질

4

반응물 1

HCID 220189706-Nitro-2-piperidin-1-ylquinoline

생성물 1

HCID 220189742-Piperidin-1-ylquinolin-6-amine

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

The product (204 mg, 0.8 mmol) of Step C and palladium hydroxide on carbon (100 mg) was suspended in methanol. The resulting mixture was degassed then stirred under hydrogen atmosphere (balloon) until all the yellow solids had dissolved. The reaction mixture was filtered through filter aid and the solvent removed under vacuum to afford the product as a brown solid, MS: m/z 228 (MH+), which was used without further purification

후처리

  1. customThe resulting mixture was degassed
  2. dissolutionhad dissolved
  3. filtrationThe reaction mixture was filtered
  4. filtrationthrough filter aid
  5. customthe solvent removed under vacuum

출처 및 근거

ORD 기록
ord-7a8c29af5c6d4ed5850e6a506f148c64
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084156B2

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