Dimethylformamide → (2E)-3-(4-Chlorophenyl)acryloyl chloride

HRID 6797

반응식

HRID 6797 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([OH:12])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:16])=O.CN(C)C=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([Cl:16])=[O:12])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6377974-Chlorocinnamic acid

생성물 1

HCID 11252649(2E)-3-(4-Chlorophenyl)acryloyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (2E)-3-(4-chlorophenyl)prop-2-enoic acid (2.0 g, 11 mmol) in 50 mL methylene chloride was added oxalyl chloride (1.05 mL, 12.1 mmol) and N,N-dimethylformamide (0.05 mL, 0.6 mmol). The resulting mixture was stirred at r.t. for 6 h. The solvent was removed under vacuum. The resulting solid was diluted with hexanes and the solvent removed under vacuum to provide an off-white solid which was used without further purification.

후처리

  1. customThe solvent was removed under vacuum
  2. additionThe resulting solid was diluted with hexanes
  3. customthe solvent removed under vacuum
  4. customto provide an off-white solid which
  5. customwas used without further purification

출처 및 근거

ORD 기록
ord-98ba0a4789094cd8bd645b484b6e0ba8
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084156B2

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