Dichloromethane → 7-Chloro-1-(3-methoxypropyl)-2-piperidin-3-ylbenzimidazole

반응식

[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[n:8]([CH2:24][CH2:25][CH2:26][O:27][CH3:28])[c:9]([CH:11]1[CH2:12][N:13]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH2:14][CH2:15][CH2:16]1)[n:10]2.[Cl:36][CH2:37][Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[n:8]([CH2:24][CH2:25][CH2:26][O:27][CH3:28])[c:9]([CH:11]1[CH2:12][NH:13][CH2:14][CH2:15][CH2:16]1)[n:10]2

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 66785571Tert-butyl 3-[7-chloro-1-(3-methoxypropyl)benzimidazol-2-yl]piperidine-1-carboxylate

생성물 1

HCID 667863667-Chloro-1-(3-methoxypropyl)-2-piperidin-3-ylbenzimidazole

출처 및 근거

ORD 기록: ord-cdde4cd22a73413f868e5dcf287efabf
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

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