Methanol → N-ethyl-3-methyl-6-nitroquinolin-2-amine

반응식

Cl[C:2]1[C:11]([CH3:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1.[CH2:16]([NH2:18])[CH3:17].CO>>[CH2:16]([NH:18][C:2]1[C:11]([CH3:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1)[CH3:17]

참가 물질

반응물 3

HCID 887Methanol

HCID 6341Ethylamine

HCID 220190042-chloro-3-methyl-6-nitroQuinoline

생성물 1

HCID 22018880N-ethyl-3-methyl-6-nitroquinolin-2-amine

실험 절차

The product (1 g, 4.5 mmol) from Step A and a solution of 2N ethylamine in methanol (5 mL, 25 mmol) were used to prepare the product according to the procedure of Example 1, Step C.

후처리

customto prepare the product

출처 및 근거

ORD 기록: ord-6fe6e3cc88c24bf59c2bd7d84afa2c25
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07084156B2

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