Ethanol → 5-Methyl-2,3-dihydro-1-benzofuran-7-amine

HRID 68137노트

반응식

HRID 68137 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.C(O)C>ClCCl.[C].[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

참가 물질

5

반응물 2

HCID 702EthanolHCID 552848275-Methylbenzofuran-7-amine

생성물 1

HCID 552848285-Methyl-2,3-dihydro-1-benzofuran-7-amine수율 87.6%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

후처리

  1. customfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
  2. customThe catalyst was removed by celite filtration
  3. customcondensed under reduced pressure
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-999ed3c345a447ad8033f1b12b11238b
출처 데이터셋
uspto-grants-2014_09
특허 번호
USRE045108E1

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