2-Chlorobenzenesulfonyl chloride → (5RS,6RS)-8-(2-Chloro-benzenesulfonyl)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

반응식

[Cl:24][c:25]1[c:26]([S:31](=[O:32])(=[O:33])[Cl:34])[cH:27][cH:28][cH:29][cH:30]1.[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5][N:6]([c:9]3[cH:10][cH:11][c:12]([CH2:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]3)[C:7]2=[O:8])[CH2:20][CH2:21][NH:22][CH2:23]1>>[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5][N:6]([c:9]3[cH:10][cH:11][c:12]([CH2:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]3)[C:7]2=[O:8])[CH2:20][CH2:21][N:22]([S:31]([c:26]2[c:25]([Cl:24])[cH:30][cH:29][cH:28][cH:27]2)(=[O:32])=[O:33])[CH2:23]1

참가 물질

반응물 2

HCID 761872-Chlorobenzenesulfonyl chloride

HCID 58056621HCID 58056621, 화합물

생성물 1

HCID 56602712(5RS,6RS)-8-(2-Chloro-benzenesulfonyl)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

출처 및 근거

ORD 기록: ord-a1cedff185d94fb29ef24ac099f967bb
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

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