반응식
[CH3:1][CH:2]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[NH:5]1)[CH3:3].[F:10][C:11]([F:18])([F:17])[CH2:12][CH2:13][C:14](O)=[O:15]>>[CH3:1][CH:2]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:14](=[O:15])[CH2:13][CH2:12][C:11]([F:18])([F:17])[F:10])[CH3:3]참가 물질
3
실험 절차
Preparation 3A was prepared from (4S)-4-(propan-2-yl)-1,3-oxazolidin-2-one (4.66 g, 36.1 mmol) and 4,4,4-trifluorobutanoic acid (5.02 g, 35.3 mmol) by the general methods shown for Preparation 1B. Preparation 3A was obtained as a colorless oil (3.64 g, 40%). 1H NMR (400 MHz, CDCl3) δ ppm 4.44 (1H, ddd, J=8.41, 3.51, 3.39 Hz), 4.31 (1H, t, J=8.66 Hz), 4.25 (1H, dd, J=9.03, 3.26 Hz), 3.13-3.32 (2H, m), 2.47-2.59 (2H, m), 2.38 (1H, dddd, J=13.96, 7.01, 3.89 Hz), 0.93 (3H, d, J=7.28 Hz), 0.88 (3H, d, J=6.78 Hz).
출처 및 근거
- ORD 기록
- ord-e6cd748b0c9f48508ac4ffc8b8f7dc87
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822454B2
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