4,4,4-Trifluorobutanoic acid → Tert-butyl 4,4,4-trifluorobutanoate

반응식

[F:1][C:2]([F:9])([F:8])[CH2:3][CH2:4][C:5]([OH:7])=[O:6].FC(F)(F)CCCC(O[C:18]([CH3:21])([CH3:20])[CH3:19])=O>>[F:1][C:2]([F:9])([F:8])[CH2:3][CH2:4][C:5]([O:7][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:6]

참가 물질

반응물 2

HCID 27770854,4,4-Trifluorobutanoic acid

HCID 86671369Tert-butyl 5,5,5-trifluoropentanoate

생성물 1

HCID 65710954Tert-butyl 4,4,4-trifluorobutanoate

실험 절차

Preparation 4A was prepared from 4,4,4-trifluorobutanoic acid (4.99 g, 35.1 mmol) using the general procedure shown for Preparation 1A. Preparation 4A (5.58 g, 80%) was obtained as a colorless oil. 1H NMR (400 MHz, CDCl3) δ ppm 2.47-2.52 (2H, m), 2.37-2.45 (2H, m), 1.46 (9H, s).

후처리

customwas obtained as a colorless oil

출처 및 근거

ORD 기록: ord-52643044e44343a0b205a137f8611126
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08822454B2

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